[HTML][HTML] The association of high-sensitivity c-reactive protein and other biomarkers with cardiovascular disease in patients treated for HIV: a nested case–control study
A De Luca, K de Gaetano Donati, M Colafigli… - BMC infectious …, 2013 - Springer
BMC infectious diseases, 2013•Springer
Background Elevated high-sensitivity C-reactive protein (hsCRP) increases the risk of
cardiovascular disease (CVD) in the general population, but its role as a predictive marker in
HIV-positive patients remains unclear. Aim of the study was to evaluate whether hsCRP or
other biomarkers are independent predictors of CVD risk in HIV-infected patients. Methods
Retrospective, nested case–control study. HIV-positive men and women (35–69 years of
age) receiving combination antiretroviral therapy (cART) were included. Cases (n= 35) had …
cardiovascular disease (CVD) in the general population, but its role as a predictive marker in
HIV-positive patients remains unclear. Aim of the study was to evaluate whether hsCRP or
other biomarkers are independent predictors of CVD risk in HIV-infected patients. Methods
Retrospective, nested case–control study. HIV-positive men and women (35–69 years of
age) receiving combination antiretroviral therapy (cART) were included. Cases (n= 35) had …
Background
Elevated high-sensitivity C-reactive protein (hsCRP) increases the risk of cardiovascular disease (CVD) in the general population, but its role as a predictive marker in HIV-positive patients remains unclear. Aim of the study was to evaluate whether hsCRP or other biomarkers are independent predictors of CVD risk in HIV-infected patients.
Methods
Retrospective, nested case–control study. HIV-positive men and women (35–69 years of age) receiving combination antiretroviral therapy (cART) were included. Cases (n = 35) had a major CVD event. Controls (n = 74) free from CVD events for at least 5 years from starting ART were matched on diabetes and smoking. HsCRP, D-dimer, P-selectin, interleukin-6 (IL-6), tissue plasminogen activator, plasminogen activator inhibitor-1 levels were measured.
Results
High hsCRP was associated with CVD risk, independently of traditional cardiovascular risk factors, HIV replication and the type of ART received at the time of sampling (adjusted odds ratio 8.00 [1.23-51.94] comparing >3.3 mg/L with <0.9 mg/L; P = 0.03). Higher IL-6 and P-selectin levels were also independently associated with increased CVD risk, although the association was weaker than for hsCRP. Higher total cholesterol and lower HDL cholesterol increased CVD risk, independent of hsCRP.
Conclusion
hsCRP may be a useful additional biomarker to predict CVD risk in HIV-infected patients receiving cART.
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