Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2: chimeric constructs …
SYM Yao, AML Ng, MF Vickers, M Sundaram… - Journal of Biological …, 2002 - ASBMB
The human (h) and rat (r) equilibrative (Na+-independent) nucleoside transporters (ENTs)
hENT1, rENT1, hENT2, and rENT2 belong to a family of integral membrane proteins with 11
transmembrane domains (TMs) and are distinguished functionally by differences in
sensitivity to inhibition by nitrobenzylthioinosine and coronary vasoactive drugs. Structurally,
the proteins have a large glycosylated loop between TMs 1 and 2 and a large cytoplasmic
loop between TMs 6 and 7. In the present study, hENT1, rENT1, hENT2, and rENT2 were …
hENT1, rENT1, hENT2, and rENT2 belong to a family of integral membrane proteins with 11
transmembrane domains (TMs) and are distinguished functionally by differences in
sensitivity to inhibition by nitrobenzylthioinosine and coronary vasoactive drugs. Structurally,
the proteins have a large glycosylated loop between TMs 1 and 2 and a large cytoplasmic
loop between TMs 6 and 7. In the present study, hENT1, rENT1, hENT2, and rENT2 were …
