FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
Background & Aims Allelic variants of fucosyltransferases 2 and 3 (FUT2/3) influence serum
levels of CA19-9, a screening parameter commonly used for detection of biliary malignancy
in PSC. We aimed at improving diagnostic accuracy of CA19-9 by determining the impact of
FUT2/3 genotypes. Methods CA19-9 levels were measured in 433 PSC patients, 41 of
whom had biliary malignancy. Genotypes for FUT3 and FUT2 were used to assign patients
to one of three groups: A, no FUT3 activity regardless of FUT2 activity; B, both FUT2 and …
levels of CA19-9, a screening parameter commonly used for detection of biliary malignancy
in PSC. We aimed at improving diagnostic accuracy of CA19-9 by determining the impact of
FUT2/3 genotypes. Methods CA19-9 levels were measured in 433 PSC patients, 41 of
whom had biliary malignancy. Genotypes for FUT3 and FUT2 were used to assign patients
to one of three groups: A, no FUT3 activity regardless of FUT2 activity; B, both FUT2 and …
