[HTML][HTML] Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation
Human mucosal-associated invariant T (MAIT) cell receptors (TCRs) recognize bacterial
riboflavin pathway metabolites through the MHC class 1-related molecule MR1. However, it
is unclear whether MAIT cells discriminate between many species of the human microbiota.
To address this, we developed an in vitro functional assay through human T cells
engineered for MAIT-TCRs (eMAIT-TCRs) stimulated by MR1-expressing antigen-
presenting cells (APCs). We then screened 47 microbiota-associated bacterial species from …
riboflavin pathway metabolites through the MHC class 1-related molecule MR1. However, it
is unclear whether MAIT cells discriminate between many species of the human microbiota.
To address this, we developed an in vitro functional assay through human T cells
engineered for MAIT-TCRs (eMAIT-TCRs) stimulated by MR1-expressing antigen-
presenting cells (APCs). We then screened 47 microbiota-associated bacterial species from …
