A historical perspective on the role of stroma in the pathogenesis of benign prostatic hyperplasia
GR Cunha, WA Ricke - Differentiation, 2011 - Elsevier
This review summarizes the concept that the neo-formation of ductal-acinar architecture in
the pathogenesis of benign prostatic hyperplasia (BPH) is due to the reactivation of
embryonic inductive activity by BPH stroma, an idea enunciated by John McNeal. The
concept is the synthesis of McNeal's astute pathological inference based upon
developmental biology and supported by the mesenchymal–epithelial interaction studies. In
a broader context, McNeal's concept of framing epithelial pathogenesis in terms of …
the pathogenesis of benign prostatic hyperplasia (BPH) is due to the reactivation of
embryonic inductive activity by BPH stroma, an idea enunciated by John McNeal. The
concept is the synthesis of McNeal's astute pathological inference based upon
developmental biology and supported by the mesenchymal–epithelial interaction studies. In
a broader context, McNeal's concept of framing epithelial pathogenesis in terms of …