Association of trimethylamine N-oxide and related metabolites in plasma and incident type 2 diabetes: the cardiovascular health study
Importance Although rodent studies suggest that trimethylamineN-oxide (TMAO) influences
glucose homeostasis and risk of type 2 diabetes, evidence in humans is limited. Objective
To examine the associations of serial measures of plasma TMAO and related metabolite
concentrations with incident type 2 diabetes, fasting plasma insulin and glucose levels, and
the Gutt insulin sensitivity index (ISI). Design, Setting, and Participants This prospective
cohort design assessed the association of plasma TMAO and related metabolite …
glucose homeostasis and risk of type 2 diabetes, evidence in humans is limited. Objective
To examine the associations of serial measures of plasma TMAO and related metabolite
concentrations with incident type 2 diabetes, fasting plasma insulin and glucose levels, and
the Gutt insulin sensitivity index (ISI). Design, Setting, and Participants This prospective
cohort design assessed the association of plasma TMAO and related metabolite …
