Germinal centers (GCs) are structures formed within B cell follicles critical for the generation
of high affinity antibodies. The evaluation of GCs in secondary lymphoid tissues has
emerged as a valuable means for understanding the immunological activity in vaccine
responses, autoimmunity and cancer. The analysis has been facilitated by advances in
sampling techniques, including non-invasive lymph node collection and fine needle
aspiration. In this study, we performed a systematic comparison between immunohistology …